Early on Saturday, a bomb attached to a car exploded in the western part of Damascus, where many diplomatic missions are located, killing one person and causing damage to property, according to state media.
The Mazze neighborhood in Damascus, where the explosion occurred, is home to the Iranian consulate, which was destroyed last month in an attack attributed to Israel.
The previous attack killed seven people, including two Iranian generals and a member of Hezbollah, and led to a direct Iranian military response against Israel for the first time, raising concerns about wider regional conflict.
In recent months, Mazze has been targeted by several airstrikes, mostly aimed at Iranian officials.
The state news agency SANA did not identify the person killed in the explosion but reported that the blast also set two other cars on fire.
According to Rami Abdurrahman, who heads the Syrian Observatory for Human Rights, the man killed in the explosion was a resident of Mazze and had a Syrian army officer identification card. Abdurrahman said the deceased had close ties with Iranians.
Hours after the explosion in Damascus, an Israeli drone reportedly targeted a car and a truck near the town of Qusair in western Syria, close to the Lebanon border, according to the Observatory and a Beirut-based pan-Arab TV station.
The strike occurred near the Dabaa air base and follows several previous drone strikes in Qusair and its suburbs targeting Hezbollah fighters who operate in the area.
While Beirut-based Al-Mayadeen TV did not report casualties, the Observatory said two Hezbollah members were killed and several others wounded in the drone strike.